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Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.

机译:乳腺癌中的表皮生长因子受体。与非恶性乳房组织的比较。

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摘要

Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
机译:使用放射性配体结合测定法在来自67个癌症和25个非恶性组织的膜制剂中测量了表皮生长因子受体。 EGFr的结合特征在肿瘤和正常乳腺膜中相似。非恶性组织中的浓度显着高于癌症中的浓度。在非恶性组织中,EGFr的浓度与类固醇受体直接相关,而在癌症中,EGFr与类固醇受体之间呈负相关。

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